Yes
There is an iron man mode in development (press F5 on the GUI) but it only supports 5 quests atm. It also works without iron man mode if you have the required items, but this includes teleport tabs and enchanted jewelry which makes it not very iron man friendly.
Prayer is not supported atm, but all quests can be done on new accs if using a good order, eg run Witch's House first for 24 HP
It's not supported on F2P worlds atm, it uses extended super antifire potions on boss fight