I know it's conjecture, but in my experience majority of my bans come from either a bad script that messes up (clicks repeatedly), bad proxy/VPN (NordVPN), or the random.dat + HWID not being isolated properly.
As far as a general direction in terms of botting evolution, I don't think one software solution will ever be enough to overcome Jagex anti-ban. Plus, if it's all consolidated to one platform/manager that now 1000's of people use instead of 100's, or 10's, it will become saturated and easily detected.
I really like the idea of OSBOT 3.0 with AI integration to allow for truly human-like playstyles and patterns. With any software comes some extent of repetitiveness, where an AI could differentiate itself every single time.