Squat, squuuaat, SQUUUAAAAT!
But really depends what you want. Power? Fast twitch muscle? Speed? Strength and size?
There are so many workouts for legs.
So what exactly are you looking for?
My usual leg day routine is:
Squats
Dead lifts
Calf raises/over head barbell squat (that's just what I call it) then calf raises in squat stance. <--- Super set those.
Ham string curls
Standing calf raises.
Quad extension.
Sometimes throw leg press in. Usually pyramid those.