If you have goldsmithing gauntlets, it's a bonus so definitely do it (since it gives 2x xp)
as for alching I released a list of all profitable items pubilicly, however your best bet is going to be buy up green d'hide bodies, air battlestaffs, and blue d'hide bodies for minimal loss.
If struggling to buy these, go for magic longbows, yew longbows, or maple longbows. But all of these methods WILL lose potential profit, whereas the ones I listed above GAIN profit.
(credits to reddit post)