With the client, off screen returns 0,0 for x,y co ordinates of the mouse position, the paint position will paint the mouse at the top left if it is not on screen.
The screenshot shows it mid way down so ill have a nosey and see what I can find
Have you selected the 'Grab gear' button on the ui? does the main hand weapon you're using match the ui? if so I will have a look and see what might be the cause.
For the first with the locator orb, please can you screenshot your settings you're using and I can copy to see if I can spot anything