Trial and error you really need to see for yourself what works and what does. Here's a little bit of info that might help you that has helped me (so far). Take this with a grain of salt.
- Verify the emails on your accounts.
- Do tutorial island manually.
- Don't bot in F2P you're almost guaranteed ban within 24 hours.
- Use mirror mode. (VIP is only $9.99)
- Do different tasks every few hours. (Questing, Other Methods, Other Skills).
- I wouldn't bot longer than 4 hours at a time until the accounts got some time / xp on it. Say at least 4-5 days with 60+ stats.
Though I said to use mirror mode there are some who will say Stealth Injection is just as safe, I personally disagree through my own testing. But if you are going to use Stealth Injection i'd limit your botting to 2-4 hours per DAY, and you should be fine.
Just keep in mind you are botting so you are going to get banned there's no run around for that. You just gotta keep going until you've found a comfortable method that works for you.