Prayer really in my opinion hasn't stopped me from anything. 1 defence, in my opinion, isn't good for staking anyways.
I've made several staking accounts.
Pretty much start off by doing Waterfall ( Will get you 30 attack and strength).
From there, Get 40 attack for rune scimitar. Then from there it's up to you.
Start off on minotaurs or something, Then move along Security Stronghold.
Flesh Crawlers/Zombies on the second floor when you're ready.
Personally, I like 40, 45, or 55 defence on dds/whipping accounts.
I get that right after 40 attack, so you can wear rune armour.
It'd be nice to get 40 attack, then quest your 40 defence, so you can wear rune platebody at 40 defence, but I cbf with quests most of the time. Especially 32 QP for Dragon Slayer.