I've actually never taken any of that, nor have I received a shot in my entire life. My parents are probably the most natural people you'll ever meet and wouldn't let the doctors give me any of that. Only drugs I've ever taken were antibiotics when I had pink eye and another time when I had whooping cough.
So yes that does mean if I get a headache I deal with it, or if I get a cavity filling I don't use novacane. It's really not that bad, instead of taking something to ease the pain just deal with it and after awhile your body gets used to it so you're not dependant on drugs for everything.