I like to get a 99 in easy to train skills. Fletching, cooking, fming, etc asap. This is so you can wear a skill cape, when you wear a skill cape and you're botting I feel like people will think you're less likely to bot and won't report you and the system might flag you less.
When I was starting the account, I would rotate between botting and manually playing. Usually I manually do quests and bot skills. Once your account looks like a no lifer, that's when I stop manually playing on it.
I switch up my bot, I usually run 3 scripts for 2-4 hours each for whatever skills I want to train. By doing this, I already got 4 99's in 2 months. I thought I would've been banned by now but I guess not.
Baby sitting scripts is also very important, since some scripts break and they'll do things that will get you flagged and you'll be able to save your account. I was using a thieving script and the bot got a genie lamp and it was trying to deposit it into the bank but you can't deposit genie lamps but it wouldn't let it, and if I didn't spot that my account would've been 100% banned.