The script requires 25 HP + 43 Prayer to do Monkey Madness I, but a slightly higher HP would improve the outcomes
I believe ranged/magic with a dwarf cannon works the best
In most cases it should be ok, but I still recommend getting 4 magic for water strike first, that greatly improves your chances there
It will safespot most bosses that can be safespotted including the first 2 phases of the Witch's House boss