There are 2 options you can use while the GUI is open
Press F5 (iron man mode) to make it automatically collect items
Press F4 (debug mode) to disable banking/exchange, this means it will require items to be in inventory
Yes
Everything that has a boss fight, has a safe spot, with few exceptions like Tourist Trap; the Jungle Demon in Monkey Madness I will not walk to you, so using magic or ranged is already a safespot