I've heard of many, many people getting banned for a static auto-clicker, where only one interval was set (EX: 1 click every second) and it was picked up by Jagex's macro detection software.
I used a Random Mouse Clicker, from Murgee, and I changed my intervals a few times a day. Also, I used milliseconds instead of seconds for a wider range.
I used this auto clicker for about seven months and my account was finally banned for Macroing Major. How is it possible that their software picked up a RANDOM mouse clicker. I hope I can get some information behind this. It seems odd that I've ran this auto-clicker for over 1,000+ hours and I finally got banned.