You clearly can, they're both in the MOBA style of gameplay.
The game has changed since closed beta.
That's like saying you can't compare the taste of fruits because more people prefer apples over oranges or vice versa.
This game has more variability involved and is constantly releasing content.
I've had friends that stopped playing league and reverted to this simply because it is fully 3D and first person.
You can gank easier and make much more strategic plays.
/Well as for ganking easier, you can peer around corners to see the opponent etc.
Instead of just waiting in bush like LoL.
Edit 2/ As for the player base. it's in BETA which means it's NEW. HerpaDerp/PostcountWarrior.