Depends.
In the beginning i didnt use vpn's or proxys.
Had 4 accounts running on my vps (same ip)
1 got perm banned, others were still running (not the same script, world)
But there is a possibility that they ban all you're accs on the same ip.
To be sure just run both accounts on a seperate proxy (like 2$ each) and keep you're own ip for main/mule.
You can run them at different times, i also do it with my main and pure.