Methoxetamine. It's, quite a substance. Here’s my (rather extensive) take.
A brief overview: MXE is a dissociative, and is an analog of Ketamine. It’s recorded use in humans is very slim, although well known in the “RC” (Research chemical) community. It is considered difficult to acquire.
By dose: This is how I reacted, by dose. (Please understand this is HIGHLY dependent on the person)
*All listed doses are by sublingual administration*
15-20mg – This is threshold.
20-45mg – This dose is light, marked by a decreased awareness, especially in conversation. A sense of slight, omnipresent confusion is about. Daily functioning is possible. (Remember, do not drive under the influence). Fatigue in strength is not as noticeable.
50mg- This would be a “recreational” dose. The user is losing perception of time. Movement may become noticeably uncoordinated. There was a sense of serenity, and peace. Loud sounds are very startling. Unlike K, the user may not feel sedated, and activates may be done while at this dose.
50-100mg – For someone without a tolerance to dissociative drugs, this may induce an “M hole”. This is a strong dose, confusion is wildly present. Daily activities like using a computer will become impossible.
100mg-500mg+ - It is possible to overshoot the m hole. An m hole is just slightly beneath full anesthesia. So this is a state where theoretically, one should be in anesthesia. Though designed to be more potent by weight then Ketamine, it actually is highly ineffective at producing anesthetic effects. I do not know why this is. This is marked by tremors, uncontrollable muscle spasms and contracting. It actually looks much like someone with fully contracted tetanus.
*A note about the m hole. The m hole is something that appears infrequently in literature. It is a state like the “k hole”. This though, is marked by complete ego death. You, as an entity, are no longer there. Objects are meaningless, as is time. Music and words are arbitrary; although the mood of the music may impact the direction of the trip. Closed and open eye visuals may occur. It is rare to remember much of this state. I personally, find it pleasant. Many find the confusion that comes with this to be overwhelming however.
Routes of administration
Sublingal - One of my favourites. Smooth come up/down. Takes some time to deliver, but is direct to the blood stream. Awful, bitter taste.
Insufflation - The drip is awful. It isn't bad going in though. Seems to take slightly more substance to deliver similar results vs other ROA's.
Suppository - Near 100% bioavailability. It's interesting to administer in this manner. This is my tied favourite ROA, it is smooth and has no bad taste.
Oral - Active oraly at almost the same dose as sublingal. It can be easy to take, but requires some time before effects are felt.
IM/IV - Not tested. May not be suited for IV. IM I speculate to be okay, I did not try this due to a lack of sterile equipment.
Vaporized - Not tested. I speculate this to be chaotic and did not attempt this for that reason.
Conclusion: A psychonaut may enjoy this. It is very unpredictable and is not at all forgiving. I enjoyed it, although I'm sure my NMDA receptors are now shot after all of this substance I have used. I will be unlikey to use it again. It has no physcial addiction potential as far as I can tell. One week of heavy, daily use will not produce withdraws. Phychological addiction potential I can't vouch for.